NanoFrontier eLD LIT-q-TOF LCMS System w/ECD : Hitachi High Technologies America

NanoFrontier eLD LIT-q-TOF LCMS System w/ECD

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Product Number:NFeLD

Overview

The Hitachi NanoFrontier is the first commercial LCMS system that combines the unparalleled separation of NanoLC with the high sensitivity of a Linear Ion Trap and the high performance of a Time-of-Flight mass analyzer. This unique hybrid design allows for operation in LIT mode for MSn (CID and ECD) or Q-TOF mode for MS/MS. The new and improved NanoFrontier eLD provides increased performance (sensitivity, resolution, and dynamic range) and a host of tools for the analysis and data processing of small and large biomolecules.

LIT-q-TOF (Linear Ion Trap-q-Time of Flight)

The NanoFrontier mass spectrometer can operate in four distinct analytical modes:

LIT-TOF mode enables MSn analysis provided by the LIT.
q-TOF mode utilizes an in-line quadrupole collision-induced dissociation (QCID) cell as an alternative fragmentation mechanism.
TOF mode, in which analytes are guided directly into the TOF analyzer, enables high molecular weight range analysis.
QuECD mode is a new high-throughput electron capture dissociation (ECD) analysis.

Hitachi's Original Electron Capture Dissociation (QuECD)

Prior to the launch of the NanoFrontier, ECD was only available in FTMS instruments. The time scale of ECD FTMS scans limits the ability to perform LC-based high-throughput analyses. The Hitachi NanoFrontier, with TOF MS, provides high-throughput intelligent control of combined ECD and CID scans for unparalleled interrogation of modified proteins.

Nano Flow HPLC

The NanoFrontier LC/MS utilizes the Hitachi NanoFrontier nLC chromatography system with DEGS (Dual Exchange Gradient System, patent pending) technology for unparalleled gradient and retention time reproducibility at true nanoflow (50nL/min).

Intelligent Software (Information Based Aquisition)

The Hitachi IBA (Information Based Acquisition) intelligent MS/MS provides enhanced protein information at reduced analysis time.