LC/MS System

An Integrated NanoLC and LIT-TOF System — Innovative Technology Dedicated for the Analysis of Proteins

The highly efficient NanoFrontier is designed to meet the demanding challenges of today's proteomics research laboratories. The hybrid mass spectrometer incorporates Linear Ion Trap technology with TOF detection (LIT-TOF) affording superior sensitivity and mass accuracy.

LIT-TOF (Linear Ion Trap - Time of Flight)

MSn analysis using the LIT enables automatic MS/MS with automatic peak selection and exclusion of monovalent ions. This is useful for detecting post-translation modifications such as phosphorylation and glycosylation sites.

Electron Capture Dissociation (ECD)

Prior to the launch of the NanoFrontier, ECD was only available in FTMS instruments. The time scale of ECD FTMS scans limits the ability to perform LC-based high-throughput analyses. The Hitachi NanoFrontier, with TOF MS, provides high-throughput intelligent control of combined ECD and CID scans for unparalleled interrogation of modified proteins.

Nano Flow HPLC

The NanoFrontier LC/MS utilizes the Hitachi NanoFrontier nLC chromatography system with DEGS (Dual Exchange Gradient System, patent pending) technology for unparalleled gradient and retention time reproducibility at true nanoflow (50nL/min).

Intelligent Software (Information Based Aquisition)

The Hitachi IBA (Information Based Acquisition) intelligent MS/MS provides enhanced protein information at reduced analysis time.

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